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Senior Research Associate II: Cell Engager Therapies _In vitro/exvivo Preclinical Pharmacology

Company: Takeda Pharmaceutical
Location: Jersey City
Posted on: January 13, 2022

Job Description:

By clicking the -Apply - button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda 's and . I further attest that all information I submit in my employment application is true to the best of my knowledge.Job DescriptionAre you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine?At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.Here, you will be a vital contributor to our inspiring, bold mission.Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law. -OBJECTIVES/PURPOSE The Cell Engager team of the Oncology DDU is seeking a highly motivated Research Associate I to join the in vitro arm of the Cell Engager team. -The interested candidate must have experience characterizing novel immune engagers for Oncology using a variety of cell-based, analytical and pharmacological assay systems. -As a member of the team, the candidate will be responsible for characterizing various tumor cell lines and engineering them to evaluate specific MOA related to target biology and engager molecule. The candidate must be skilled at analyzing in vivo studies to help establish PK / PD / efficacy relationships. -The position will require the individual to be hands-on. The individual will work very closely with other functional groups within the ODDU as well as DMPK, DSRE, Global Biologics as part of a matrixed organization. -He/She will demonstrate effective communication and documentation of results. Ideal applicant will be team-oriented, possess excellent communication and organizational skills.ACCOUNTABILITIES

  • Supporting therapeutic and pipeline programs: Will entail, biologic modalities and -screening including HT assay development, and MoA assays using cell lines and primary immune cells (epithelial assay systems, CAF assay systems, immune cells -T cells, monocytes, DCs etc
  • Spends 80% time in the laboratory
  • Supporting activities from in vivo team: Human and mouse exvivo assays, Exvivo analysis from tissue biopsies
  • Work closely with project leaders to evaluate the dual antigen targeting strategies in Immunotherapies as part of novel COBRA design
  • Conduct T cell Activation and Cytotoxicity Assays, ELISA, Octet, MSD assays for biochemical and functional characterization of new engager molecules with minimum supervision
  • Performs cloning, PCR, Lentivirus Transductions, Western Blot, Cell Culture
  • Collaborates with IOI, C2H and translational teams to help support MOA studies related to COBRAs and other Cell Engagers.
  • Supports target validation and biomarker assays by characterizing binding, effector function, activity, mechanism of action, internalization
  • Participate in analysis of in vivo studies to help establish PK / PD / efficacy relationships.
  • With time can serve as the pharmacology/IO biology rep on project - teams
  • Identify state of the art experimental protocols and relevant assays for improved detection and analysis in various matrices.
  • Interrogates novel biology as it relates to new COBRA designs invitro.
  • Is hands on at the bench working as part of a matrix team.
  • Support target validation and biomarker discovery.
  • Executes experiments with minimum supervision and delivers comprehensive high quality data sets to enable decision making
  • Keep up with published literature centered around cancer targets and IO therapies relavant to the Takeda 's CE strategy
  • Utilizes relevant information, technology and resources, contributing to complex team problem resolution and objectives
  • Interprets results of complex experiments
  • Prepares and presents comprehensive technical or project reports and formal presentations / posters - to full range of internal/external audiences.
  • Maintain laboratory notebooks and follow laboratory practices in compliance
  • Demonstrates theoretical knowledge of large molecule therapeutics (Abs, bispecifics, etc)
  • Keeps current with emerging trends in immune cell engagers for application in cancer therapy
  • Able to clarify requests and provide suggestions and put data into context especially in context of assay design and quality of data
  • Demonstrates in-depth technical knowledge within various assay development platforms
  • Independently investigates new immunological techniques, that can be applied to team projects
  • Serves as the in vitro immunobiology rep on projects providing key scientific feedback to advance programs in a matrixed environment.
  • Manages own workload with minimum supervision
  • Scientifically independent
  • May provide information to - project teams to influence direction, align with departmental goals and/or business
  • Conducts scientific presentations to internal audiences
  • Collaborates with others across sites, and acts as scientific resource for in vitro pharmacology of COBRA molecules
  • Expected to participate in new target identification / validation process
  • Strives towards expanding scientific knowledge in immunology
  • Receives high level instructions on work; determines methods on new assignments; demonstrated greater independence; may manage internsEDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS: -
    • MS with 1+ -BS with 3+ years experience, with a background Immunology, Pharmacology, Oncology.
    • Industry experience with a focus on Immunology, or Oncology is preferred
    • Current knowledge of oncology research, drug discovery and development with an emphasis on immune cell activation, checkpoint blockade, exhaustion pathways as well as markers for anti-tumor efficacy
    • Proven ability to evaluate biologics using various assays including, binding, cytotoxicity, proliferation, activation, internalization, fluorescence imaging, reporter based etc - is required
    • Experience culturing and maintaining human tumor cell lines and primary human/cyno cells including but not limited to T cells is required
    • Experience with characterization of tumor cell lines is required
    • Experience with cell engineering and gene editing is preferred
    • Hands -on basic experience with multi-color flow cytometry, molecular biology techniques (PCR, Gibson assembly, cloning etc),Western blot ,Protein Simple systems, ELISA, MSD, RNA isolation qPCR and other standard cell based and non-cell based biochemical assays -is required
    • Experience with biologics is nice to have (Antibodies, ADCs, Cell therapies etc)
    • Experience in the design and construction of mammalian expression vectors and cell transfection and/or viral-mediated cell transduction, preferably of primary immune cells is preferred
    • Knowledge of drug discovery process and pharmacology is essential.
    • Use of scientific databases and application for data management and data analysis
    • Excellent written and verbal communication skills,
    • Excellent team player with a can-do attitude with an ability to thrive in a dynamic -biotech- like - environment and work in cross-functional project teams
    • Innovative and critical thinking
    • Self-motivated, collaborative with excellent time management and organizational skillsLOCATION & TRAVEL REQUIREMENTS: - - - - - - - - - This role is considered a hybrid position and you must be able to work onsite in Cambridge, MA on average 2-3 days per week.WHAT TAKEDA CAN OFFER YOU:
      • 401(k) with company match and Annual Retirement Contribution Plan
      • Tuition reimbursement Company match of charitable contributions
      • Health & Wellness programs including onsite flu shots and health screenings
      • Generous time off for vacation and the option to purchase additional vacation days
      • Community Outreach ProgramsEffective November 1, 2021, absent an approved religious or medical reason, all US office-based and lab-based Takeda employees who work fully on-site or in a hybrid model (as determined by Takeda) must be fully vaccinated to work at a Takeda site or to engage with Takeda colleagues or anyone else on behalf of Takeda. As of the same date, absent an approved religious or medical reason, US field-based employees, employees must be fully vaccinated in order to continue in their current roles. - US employees who work at a Takeda manufacturing facility, and those who work at a BioLife center or BioLife lab, may be subject to different guidelines. Candidates are encouraged to speak with their recruiter to seek further information on the applicable guidelines for the Business Unit/Function for which they have applied.Empowering Our People to ShineDiscover more at takedajobs.comNo Phone Calls or Recruiters Please.In accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply.#LI-JT1EEO StatementTakeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.LocationsBoston, MAWorker TypeEmployeeWorker Sub-TypeRegularTime TypeFull time

Keywords: Takeda Pharmaceutical, Jersey City , Senior Research Associate II: Cell Engager Therapies _In vitro/exvivo Preclinical Pharmacology, Healthcare , Jersey City, New Jersey

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